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Drugs on the CVS


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[Front]


What are some causes of arrythmias
[Back]


Ectopic pacemaker activity --> damaged area of myocardium becomes depolarised and spontaneously active Afterdepolarisations --> Abnormal depolarisations following the action potential Re-entry loops --> Conduction delay and Accessory pathway

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What are some causes of arrythmias
Ectopic pacemaker activity --> damaged area of myocardium becomes depolarised and spontaneously active Afterdepolarisations --> Abnormal depolarisations following the action potential Re-entry loops --> Conduction delay and Accessory pathway
What are afterdepolarisations
Anything which prolongs the duration of the action potential can allow afterdepolarizations to occur On a ECG it comes at as a longer QT interval due to longer AP More likely with high [Ca2+] Can cause premature AP to fire leading to arrythmias
What is the re-entrant mechanism for generating arrythmias
Incomplete conduction damage (unidirectional block) Excitation can then take a longer route to spread the wrong way through a damaged area , setting up a circus of excitation And these can give rise to arrhythmias
What is Wolff Parkinson White syndrome
Example of a Paroxysmal supraventricular tachycardia In this condition there are additional points of conductivity between the atria and ventricles Additional accessory pathway This is called the Bundle of Kent This basically acts as a second AV node but less regulated and can lead to arrhythmic activation of the heart
What are the 5 classes of drugs used to treat arrhythmias
Drugs that block voltage sensitive Na+ channels Antagonists of beta-adrenoreceptors Drugs that block K+ channels Drugs that block Ca2+ channels Others e.g. Adenosine, Magnesium etc.
What is the mode of action of Lidocaine
Sometimes used following MI if patient shows signs of ventricular tachycardia → given IV Damaged areas of myocardium may be depolarised and fire automatically More Na+ channels are open in depolarised tissues and Lidocaine can block these channels and prevent automatic firing
What is the mode of action of beta blockers and/or beta-adrenoreceptors antagonists
Blocks sympathetic action Act at Beta-1 adrenoreceptors in the heart Decreases the slope of pacemaker potential in the SA node Can prevent supraventricular tachycardias and arrythmias Also reduces Oxygen demand so it reduces myocardial ischaemia which is beneficial post MI
Mode of action of drugs that block K+ channels
Prolongs the AP Mainly by blocking K+ channels This lengthens the absolute refractory period Prevents another APP from occurring too soon Not generally used tho Used to treat tachycardia associated with Wolff Parkinson-White syndrome (re-entry loop due to an extra conduction pathway)
Mode of action of Ca2+ channel blockers
Example is Verapamil Decreases the slope of pacemaker potential at SA node Decreases AV nodal conduction Decreases force of contraction Also cause some coronary and peripheral vasodilation The dihydropyridine Ca 2+ channel blockers are not effective in preventing arrhythmias, but do act on vascular smooth muscle
Mode of action of adenosine
Produced endogenously Acts on A1 receptors at AV node Enhances K+ conductance Hyperpolarized cells of conducting tissue Stops heart momentarily and resets the rhythm Administered IV
What are some features of heart failure
Chronic heart failure is the failure of the heart to provide sufficient output to meet the body’s requirement Reduced force of contraction Reduced cardiac output Reduced tissue perfusion Oedema → due to back pressure
How do ACE inhibitors work
Drugs which inhibit the action of angiotensin converting enzyme are important in the treatment of heart failure Prevent the conversion of angiotensin I to angiotensin II Decrease vasomotor tone ( blood pressure is reduced ) Reduced afterload of the heart Decrease fluid retention so there is decrease in blood volume Reduce preload of the heart Reduce work load of the heart Angiotensin II receptor blockers (ARBs) have similar effects e.g. losartan
What are some factors that induce positive lusitropy
Lusitropy --> refers to the ability of the myocardium to relax following excitation contraction coupling Beta adrenergic agonists → Phospholamban is an antagonist of SERCA in the non phosphorylated state
What are some factors that induce negative lusitropy
High cytoplasmic calcium SERCA not working properly Alkalosis Increased affinity of troponin C Cardiac glycosides --> cardiac glycosides inhibit the Na+‐K+‐ATPase on cardiac and other tissues, causing intracellular retention of Na+, followed by increased intracellular Ca2+ concentrations
What are the action of cardiac glycosides
Ca2+ is extruded via the Na +-Ca 2+ exchanger Driven by Na+ moving down its concentration gradient Cardiac glycosides block the Na+/K+ ATPase Hence leads to rise in Na+ conc intracellularly Rise in intracellular Na + leads to decrease in activity of Na + -Ca 2+ exchanger and this causes increase in [Ca2] Hence more is stored in the sarcoplasmic reticulum Increased force of contraction → Positive inotropic effect Cardiac glycosides also increase vagus nerve activity → parasympathetic NS so slows down HR and AV conduction
What is the action of organic nitrates
Action on the venous system, venodilation leads to lower preload Reduces workload of the heart Heart fills less therefore force of contraction is reduced This lowers oxygen demand Venodilation reduces venous pressure and the return of blood to the heart Action on coronary arteries improves O2 delivery to the ischaemic myocardium and acts on collateral arteries rather than arterioles so dilation increases amount of blood flow