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Sepsis Infection


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[Front]


What is a septic shock
[Back]


Dramatic drop in blood pressure which can lead to organ problems and death

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13 questions
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What is a septic shock
Dramatic drop in blood pressure which can lead to organ problems and death
What does inflammation do
Vasodilation, increases vascular permeability to allow leukocytes to enter the site of infection.
What is hypovolaemia
Loss of blood volume relating to blood loss or plasma loss
What does obstruction of the capillary cause
Decreased oxygen delivery/ removal of waste products which can lead to multiple/single organ failure
How does Systemic inflammation play a part in coagulation
Tissue factor mediated and starts thrombin generation, inhibits anticoagulant mechanism/fibrinolysis
To recognise sepsis what do you use
TIME ( Temperature, Infection , Mental decline , extremely ill )
Why does gram-ive bacteria are the main cause of sepsis?
They contain LPS ( lipopolysacchiride ) which activates macrophages and NK cells
What is now used and what score is needed
SOFA ( Sequential Organ Failure Assesment ) , needs an increase of 2 or more to have sepsis
What is the sepsis 6 bundle?
Give oxygen, take cultures , broad antibiotics, IV fluids, take lactate levels and urine outputs
What can result in after absolute hypovolaemia
Decrease in systemic vascular resistance which can lead to decrease BP
What causes absolute hypovolaemia
Leakage in the capillaries causing reduced blood volume and decrease in cardiac output and systemic vascular resistance which can lead to less oxygen and hypoxia.
During sepsis what happens to coagulation?
It is accelerated leading to tiny blood clots forming in capillaries