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level: Level 3

Questions and Answers List

level questions: Level 3

QuestionAnswer
have REDUCED OVERALL DRUG CLEARANCE.DRUGS highly bound to plasma protein
For a drug that is metabolized mainly by the liver, binding to plasma proteins prevents the drug from entering the__, resulting in reduced drug metabolism by the liver.HEPATOCYTES
1 at LOW DRUG CONCENTRATIONS, most of the drug may be __ 2 whereas at HIGH DRUG CONCENTRATIONS, the protein- binding sites may become __, with a consequent rapid increase in the __1 bound to the protein 2 saturated, free drug concentrations
AMINO ACIDS THAT BINDS TO ACIDIC DRUGSHistidine Arginine Lysine
AMINO ACIDS THAT BINDS TO BASIC DRUGSGlutamic Acid Aspartic Acid
PROTEIN BINDING IS DETERMINED BY:1 Dialysis 2 Ultracentrifugation 3 Ultrafiltration 4 Sephadex-gel filtration chromatography (resin) 5 Molecular filtration 6 Electrophoresis 7 Agar plate test DUU SMEA
The Pharmacokinetic IMPORTANCE OF PROTEIN BINDING1 Drug-protein binding INFLUENCES THE DISTRIBUTION EQUILIBRIUM OF THE DRUG 2 Plasma proteins EXERT A BUFFER and TRANSPORT FUNCTION in the DISTRIBUTION process 3 Only FREE and UNBOUND DRUG ACTS and can LEAVE the circulatory system and DIFFUSE INTO THE TISSUE
Pathological Conditions in which Plasma Concentration of ∂1-ACIDGLYCOPROTEIN is increased1 Cancer - Carcinoma, Leukemia, Lymphoma, Malignant melanoma, myeloma 2 Inflammation - Crohn’s disease, Inflammatory polyarthritis, pneumonia, rheumatoid arthritis, ulcerative colitis, systemic erythematosus 3 Myocardial Infarction Trauma - Burns, extensive tissue damage, surgery, transplantation