PHARMACOLOGY 1: • also causes a DOWNWARD SHIFT of the Emax,
with no change in the EC50 value of an
agonist
• binds to a site (allosteric site) and prevents
the receptor from being activated by the
agonist
• Ex: Picrotoxin in GABA receptors

Question

• also causes a DOWNWARD SHIFT of the Emax, 
with no change in the EC50 value of an 
agonist
• binds to a site (allosteric site) and prevents 
the receptor from being activated by the 
agonist
• Ex: Picrotoxin in GABA receptors

LEIGHTON DWIGHT OBILLOS · Accepted Answer

Allosteric Antagonists

PHARMACOLOGY 1

• also causes a DOWNWARD SHIFT of the Emax, with no change in the EC50 value of an agonist • binds to a site (allosteric site) and prevents the receptor from being activated by the agonist • Ex: Picrotoxin in GABA receptors

Allosteric Antagonists

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