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Red Blood Cell Disorders

Review on high yield concepts in Red Blood Cell Pathology. Designed for flashcard mode.


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Red Blood Cell Disorders


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[Front]


due to decresed hemoglobin production
[Back]


microcytic anemia

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75 questions
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Heme composition
Iron+ protophorphrin
Most common type of anemia
Iron deficiency anemia
Two most common causes of macrocytic anemia
Folate or Vitamin B12 deficiency
Two main causes of normocytic anemia
Peripheral destruction and underproduction
Laboratory findings when Storage Iron is depleted
Decresed ferritin, increased TIBC
Laboratory findings when serum iron is depleted
Decreased serum iron, decreased % saturation
Why is it necessary to sequester iron during chronic inflammation
To prevent bacteria from accessing iron which is necessary for their survival
Lab findings in anemia of chronic desease (ferritin, TIBC, serum iron, % saturation)
Increased ferritin, decreased TIBC, decreased serum iron, decreased % saturation, increased FEP
Rate limiting step in protoporphyrin synthesis
Aminolevulinic acid synthetase (ALAS) converts succinyl CoA to aminolevulinic acid (ALA)
Laboratory findings of sideroblastic anemia
Increased ferritin, decreased TIBC, increased serium iron and increased % saturation (iron overload state)