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level: Musculoskeletal drugs

Questions and Answers List

level questions: Musculoskeletal drugs

True or false: acetaminophen treats both pain and inflammation associated with osteoarthritis.False. Acetaminophen does not treat inflammation.
True or false: acetaminophen is ideal for treating older patients because it has fewer side effects than NSAIDs.True.
True or false: salicylate drugs treat both pain and inflammation.True.
True or false: there are no long-term side effects from taking salicylate drugs.False. They cause stomach irritation and gastric ulcers long-term.
Types of salicylate drugsaspirin (Bayer, Ecotrin), magnesium salicylate (Doan's)
How is Ecotrin administered?It is an enteric-coated tablet that is administered rectally.
Prostaglandins cause:inflammation
NSAIDs treat pain and inflammation by:inhibiting production of prostaglandins
NSAIDsdiclofenac (Cataflam, Voltaren), fenoprofen (Nalfon), indomethacin (Indocin), keptoprofen, meloxicam (Mobic), naproxen (Aleve, Naprosyn), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril)
What was the first Rx topical skin gel approved by the FDA for treating osteoarthritis?diclofenac (Voltaren)
Indocin (indomethacin) is used to treat osteoarthritis and ..:it is given intravenously to newborns to close persistent patent ductus arteriosus.
2 NSAIDs used only to treat animals include:carpofen (Rimadyl) for cats and dogs; and phenylbutazone (Butazolidin) for horses.
COX-2 (cyclooxygenase) is a(n):enzyme that plays a role in production of prostaglandins.
COX-2 inhibitor drugs work by:selectively inhibiting COX-2, which decreases production of prostaglandins.
The only COX-2 inhibitor still on the market is:Celebrex (celecoxib)
COX-2 inhibitors that were removed from the market for increasing the risk of heart attacks and strokes are:rofecoxib (Vioxx) and valdecoxib (Bextra)
True or false: corticosteroid drugs used to treat osteoarthritis are analgesics.False, they are anti-inflammatory, used to treat acute flare-ups of inflammation of joints.
Corticosteroids that can be directly injected into a jointbetamethasone, dexamethasone, methylprednisolone, and triamcinolone)
hydrocortisoneCortef and Solu-Cortef
Medrol and Solu-Medrolmethylprednisolone
triamcinoloneAristospan Intra-articular and Kenalog-10
secreted by the synovial membrane of a joint to maintain the thick, slippery quality of synovial fluid.hyaluronic acid
2 brand name drugs for hyaluronic acid are:Hyalgan and Synvisc
The drug hyaluronic acid is derived from:the combs of chickens
Limbrel (flavocoxid) is categorized as a:medical food product (it contains plant antioxidants)
Lipoxygenase (LOX) is a(n):enzyme that converts arachidonic acid into prostaglandins.
prostaglandins also do this:protect the stomach mucous membranes.
Osteo-Bi_Flex contains:Glucosamine and chondroitin
glucosaminehelps the body produce cartilage
chondroitinhelps cartilage retain water content
Types of drugs used to treat osteoarthritis:acetaminophen, salicylate drugs, NSAIDs, COX-2 inhibitors, and corticosteroids.
Rheumatoid arthritis is caused by:autoimmune response where the immune system destroys cartilage, connective tissue, and joints.
The first drugs used to treat RA are:acetaminophen, salicylate drugs, NSAIDs, COX-2 inhibitors, and corticosteroids.
Drugs used to treat RA that are more intensive include:gold compound drugs, monoclonal antibody drugs, Janus kinase inhibitor drugs, and immunosuppressant drugs
Gold compound drugs treat RA by:inhibiting macrophages in the immune system from attacking joints.
Monoclonal antibody drugs treat RA by:preventing lymphocytes from making antibodies against joint tissues, and by inhibiting tumor necrosis factor.
3 substances that can cause inflammation are:prostaglandins, tumor necrosis factor, and cytokines
Janus kinase is a(n)enzyme within cells that triggers cytokines (which are released by WBCs during an autoimmune response.)
azathioprine and cyclosporine treat RA bysuppressing the immune response
Abatacept treats RA by:inhibiting T lymphocytes that attack joint tissues
Anakinra treats RA by:blocking interleukin-1 from binding to receptors on cartilage cells and destroying cartilage.
Etanercept treats RA by:blocking tumor necrosis factor and by suppressing the immune response.
hydroxychloroquine treats RA by:it is unknown how hydroxychloroquine works to treat RA.
Leflunomide treats RA by:controlling an overactive immune response
Methotrexate is used to treat both RA and:cancer (it is a chemotherapy drug)
sulfasalazine has what kind of therapeutic effect?anti-inflammatory
Brand name drugs for hyaluronic acid include:Hyalgan and Synvisc
Limbrel is the brand name for what drug?flavocoxid
Topical drugs used to treat pain of osteoarthritis include:Aspercreme, Capsin, Icy Hot, Bengay, Musterole Deep Strength Rub, Therapeutic Mineral Ice
What does Aspercreme contain?trolamine salicylate
What ingredients make up Bengay, Musterole, and Therapeutic Mineral Ice?methyl salicylate and menthol)
Brand name for auranofinRidaura
Generic drug name for gold sodium thiomalate:Aurolate
Monoclonal antibody drugs used to treat RA include:Humira, Cimzia, Simponi, Remicade, Rituxan, and Actemra
generic drug name for Humira:adalimumab
generic name for Cimzia:certolizumab
generic name for Simponigolimumab
generic name for Remicadeinfliximab
generic name for Rituxanrituximab
generic name for Actemratocilizumab
What type of drug is Xeljanz (used to treat RA)?It's a Janus Kinase inhibitor drug
generic name for Xeljanztofacitinib