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level: Drug reactions

Questions and Answers List

level questions: Drug reactions

QuestionAnswer
What can cause drug induced lupusprocainamide, which is used to treat irregular heart rhythms, and hydralazine
How to assess if drug has caused a certain reactionChallenge dechallenge rechallenge
What stains enamel blackiron salts
What might cause palatal pigmentationAnti malarial drugs
Examples of drugs that can cause staining□ Amiodarone □ Bleomycin □ Chloroquine □ Chlorpromazine □ Gold □ Hydroxychloroquine □ Mepacrine □ Methyldopa □ Minocycline □ Premarin □ Quinidine (anti-malarial)
Symptoms of drug induced gingival overgrowthInflammatory overgrowth  (hypertrophy) of soft tissue between the teeth (buccal  and labial gingivae  predominant)
Drugs that commonly cause this includeNifedipine (and other  dihydropyridine CCBs) Ciclosporin Phenytoin
Which drugs can cause the following -Thrombocytopenia  bleeding at the gingival margins,  which may be spontaneous or may  follow mild trauma (such as  toothbrushing) Examples include:Quinine Sulphonamides Heparin
What can the following drugs cause Methotrexate Nicorandil NSAIDs Gold Penicillamineoral ulceration
What is a FDESpecific recurring site in the oral cavity which will flare up when a specific drug is taken e.g. Barbiturates NSAIDs Sulfonamides Tetracyclines
Sloughing and oedema can be caused by whatChemotherapy/ immunosuppresion
What is licenplanusLichen Planus =  Autoimmune,  Mucocutaneous disorder  with oral, genital and or skin  lesions (typically white)
If the lichenplanus has an unidentified cause what is it reffered to asA lichenoid reaction
What drugs can casue lichenplanusNSAIDs Antihypertensives à All classes Dental amalgams Penicillamine Anti‐malarials
What drugs/ therapies can cause pseudo oral candidiasisUse of broad spectrum antibiotics Immunosuppresants (inc corticosteroids) Cytotoxic therapies OHI can also help
Dysgeusia vs hypogeusia vs parageusiaDistorted taste e.g. sweet taste sour
What metal ion do drugs contain that can cuase a metallic taste sensationZinc
Drugs which can affect tastechemotherapy
What are these drugs likely to cause- antimuscarinics (anticholinergics),  antidepressants (TCAs, SSRIs), baclofen, clonidine,  and tizanidine Excessive use of diureticsXerostomia
Pain in the salivary glands may be due to what class of drugsAntihypertensives
Tx of xerostomiaSialogogue (such as pilocarpine or sugar free gum
What type of drug is Clozapine and what can it causeAnti psychotic and can cause hypersalivation
What can these drugs cause ACE inhibitors Antithyroid drugs Methyldopa Sulfonamides Phenothiazines Protease inhibitorsSialadenitis
What is angiodemaSwelling of the inner layers of the skin commonly lips- often caused by dental treatment
pemphigusBlisters that rupture
PemphigoidBlisters stay entact
penicillamine can causeDrug induced pemphigoid
What is stevens johnson syndromeMassive life threatening ulceration of the mouth often involving erthema multiforme can be caused by penicillins & sulfonamides, anti‐epileptic  drugs (esp carbamazepine)