| Competitive inhibition | - Similar shape to substrates
- Compete with substrates to bind to active site
- No reaction takes place
- Blocks active site instead
- Forms enzyme-inhibitor complex |
| Competitive inhibition and concentration | - How much the enzyme is inhibited depends on the relative concentrations of the inhibitor and the substrate
- High concentration of inhibitor = more blocking of the active sites
- High concentration of substrate = less blocking of the active sites, increasing rates of reaction |
| Non-competitive inhibition | - Binds to the enzyme away from its active site (allosteric site)
- Changes shape of active site
- Substrates can no longer bind to enzyme
- They don't 'compete' as they are different shape |
| Site that non-competitive binds to | - Allosteric site |
| Non-competitive inhibition and concentration | - Increasing substrate concentration wont make a difference to the reaction rate |
| What is End Product Inhibition (inhibition feedback) | - When the end product of the series of enzyme controlled reactions will inhibit the first enzyme in the series
- To stop the reaction
- Often non-competitive inhibition |
| Non-competitive inhibition and rates of reaction (in terms of feedback) | - Non-competitive inhibitors always slow rates of reaction
- Controls reaction |
| Competitive inhibition and rates of reaction (in terms of feedback) | - Competitive inhibitors don't slow down the rate of reaction if the substrate concentration is high
- So it cant control the reaction |
