molecular basis of inheritance - Details

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How are DNA fragments charged

Negatively charged

These are short sequences of DNA nucleotides which are synthesized discontinuously and later linked together by an enzyme DNA ligase to create the lagging strand during DNA replication.

Okazaki fragments

Which RNAs should be most abundant in animal cell

R-RNA ( 80 percent of the cell ribosomal content)

What is the criterion for DNA fragments movement on agarose gel during gel electrophoresis

The smaller the fragment size, the farther it moves

When does DNA replication in bacteria occurs

Prior to fission

Where is rRNA formed ?

Nucleolus

If there are 999 bases in an RNA that codes for a protein with 333 amino acids, and the base at position 901 is deleted such that the length of the RNA becomes 998 bases, how many codons are altered?

What are Ribosomes composed of ?

RNA + Protein

CDNA probes are copied from the messenger RNA molecules with the help of what ?

Reverse transcriptase

Out of the three bases of the codon which is the least important?

The third base of the codon is the least specific and hence least important.

Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis?

Neomycin

Amino acid sequence, in protein synthesis is decided by the sequence of which RNA

MRNA

One gene-one enzyme hypothesis was postulated by

Beadle and Tatum

One turn of the helix in a B-form DNA is approximately

3.4 nm

During protein synthesis in an organism, at one point the process comes to a halt. which codons could bring it to a halt

UAG, UGA, UAA

Thymine is also known as a pyrimidine nucleobase. what is the other name?

5-Methyl uracil

The association of histone H1 with a nucleosome indicates

That DNA will be packed normally in the cells

What is read in a contiguous fashion in mRNA

A codon

Removal of introns and joining the exons in a defined order in a transcription unit is called

Splicing

The DNA is condensed into a Chromatin Fibre

Semiconservative replication of DNA was first demonstrated in

Escherichia coli

The Okazaki fragments in DNA chain growth

Polymerize in the 5'-to-3' direction and explain 3'-to-5' DNA replication

Whose experiments cracked the DNAand discovered unequivocally that the genetic code is "triplet"?

Nirenberg and Mathaei

The one aspect which is not a salient feature of genetic code, is its being

Ambiguous

What cell/organism does not follow the central dogma of molecular biology?

HIV

Which enzymes will be produced in a cell in which there is a nonsense mutation in the lac-y gene ?

B-galactosidase

Functioning unit of DNA containing a cluster of genes under the control of a single promoter

Operons

Several ribosomes attached to a single mRNA form?

Polysome

What are the binding site of t-RNA with m-RNA and amino acids ?

M-RNA-anticodon loop and amino acid-CCA end

What does allolactose acts as ?

Inducer

One gene one enzyme relationship was first established in which organism?

Neurospora crassa

A gene containing multiple exons and at least one intron is termed as

Split gene

A plasmid and was one of the first widely used E. coli cloning vectors. Created in 1977 in the laboratory of Herbert Boyer

PBR322

Which one of the following pairs of nitrogenous bases of nucleic acids, is wrongly matched with the category mentioned against it?

Adenine, Thymine - Purines

In the DNA molecule

There are two strands which run antiparallel one in 5' ->3' direction and other

Gene which is responsible for the synthesis of a polypeptide chain is

Structural gene

Which of the following bond is not related to nucleic acid?

Peptide bond

It is the example of repressible gene ( ON plus co-repressor gives OFF)

Tryptophan operon

The end product of a metabolic pathway may bind a repressor to make the latter active enough to bind to the operator. the end product is called?

Co reppresor

DNA is not present in which cell organelle ?

Ribosomes

The cutting of DNA at specific points became possible with the discovery of

Restriction enzyme

RRNA is sythesized in

Nucleus

In the absence of lactose the repressor binds with the operator region and it was elucidated by francois jacob and jaque monad.

Lac operon

Commonly used vectors for human genone sequencing are

BAC and YAC

Analysis of chromosomal DNA using southern hybridisation technique does not use

PCR

What is a functioning unit of DNA containing a cluster of genes under the control of a single promoter.

Operon

In plants and animal cells chromatids are made up of

DNA,RNA HISTONE AND NON HISTONE

Codon with dual functions is

AUG

Gene regulation governing lactose operon of E.COLI that involves the lac 1 gene product is

-ve and inducible because repressor protien prevents transcription.

The most unstable RNA is

Heterogenous nuclear RNA

Hargobind khora contributed to genetic engineering by synthesing

Artificial gene

The experiment demonstrated that DNA replicated semi-conservatively, meaning that each strand in a DNA molecule serves as a template for synthesis of a new, complementary strand. who did this expeeriment?

Meselson and Stahl

The DNA fragments separated on an agarose gel can be visualized after staing with

Aniline blue

The final proof for dna as the genetic material came from the experiments of

Heshey and chase

Balbiani rings are found in

Polytene chromosomes

Un DNA helix, cytosine is paired with guanine by

Three hydrogen bonds

Which RNAs pick up specific amino acid from amino acid pool in the cytoplasm to ribosome during protien synthesis

TRNA

Transporon was discovered by

B.Mc Clintock

Okazaki fragments form

Lagging strand

Wobble hypothesis was given by

F.H.C. Crick

DNA profiling

It looks like clover leaf in the three dimentional structure is true for

TRNA

Which codon codes for the same information as UGC

UGU both code for cysteine

TATA box of eukaryotic promoter lies

About 25 bp upstream of the transcription start site

There are three genes a,b,c. percentage of crossing over betweena and b is 20 percent , b and c is 28 percent, and a and c is 8 percent. what is the sequence of genes on chromosome?

B,a,c

UUU codon goes with which amino acid

Phenylalanine

GGG codon goes with which amino acid

Glycine

UCU codon goes with which amino acid

Serine

CCC codon goes with which amino acid

Glycine

AUG codon goes with which amino acid

Methionine

Histones are basic protiens of major importance in packaging of eukaryotic DNA. DNA and histones comprise chromatin forming the bulk of eukaryotic chromosome

Histones are of five major types H1,H2A,H2B,H3 AND H4

MRNA is attached to the ribosome by which means

Protien ribophorin 1 and 2

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