| NAEGLERIA FOWLERI is a free living Amoeba found in? | Distributed world wide, they are found in soil, lakes, brackish water, hot springs, heated swimming pools. |
| NAEGLERIA FOWLERI is an organism that alternated between Amoebic form and flagellated form, which form is found in tissue? | Amoebic form is found in tissue. |
| contraction of NAEGLERIA FOWLERI? | they gain entry via nasal mucosa during swimming, travel along the olfactory nerve and gain entry to the brain via the cribiform plate. |
| clinical disease caused byNAEGLERIA FOWLERI? | PAM |
| NAEGLERIA FOWLERI cause PAM where cases are fetal, symptoms include? | headaches, fever, rigid neck, mental confusion coma and eventually death. |
| the life cycle of NAEGLERIA FOWLERI | 1)cyst in water, 2) trophozoite dvelops, may becomem flagellated, 3)divide by binary division, promitosis, 4) penetration of nasal mucosa, 5) migrate olfactory nerve to the brain |
| NAEGLERIA FOWLERI divides by binary division with nuclear membrane intect, the process is known as | promitosis |
| the diagnostic stage of NAEGLERIA FOWLERI? | trophozoite in csf and brain tissue, flagellated form occasionally in csf |
| the 3 stages in the life cycle of NAEGLERIA FOWLERI | cyst, trophozoite and the flagellated forms |
| which of the stages in the life cycle of NAEGLERIA FOWLERI will most likely be found in the environment? | the cyst. |
| an individual went for a swim in a hot spring: a) what is the causative agent of the t disease he may contract? b) what is the disease ? c) what symptoms may develop in 1-2 days ? d) and within 9 days? | a)NAEGLERIA FOWLERI.
b) PAM
c) headaches, fever, nausea and vomiting
d) meningeo-encephalitis, irrational behavior, coma leading to death |
| diagnosis of this disease is usually during autopsy where csf show motile organism. | PAM caused by NAEGLERIA FOWLERI |
| NAEGLERIA FOWLERI can be cultured on | non-nutrient agar containing bacteria |
| which form of NAEGLERIA FOWLERI will be found in a) period of low nutrition? b) prolonged adverse condition? | a) flagellated form, b) cyst |
| a young boy read about diseases contracted from the environment. He is particularly concerned about contracting PAM. he seeks your advice as a 3rd year medical student about the least likely place to contract this disease. a) where b) why? | a) sea water
b)NAEGLERIA FOWLERI is sensitive to chlorine |
| staining of csf sample being screened for NAEGLERIA FOWLERI can be done with? | H&E, Giemsa-Wright stain |
| lab diagnosis of NAEGLERIA FOWLERI | wet mount, CT and MRI of head, staining, fluorescent antibody immunofluorescent, indirect immunofluorescent |
| the pathology of PAM | Hemmorhage and Nercrosis. mainly in the frontal cortex. |
| case 1a) you are a 3rd year medical student present at an autopsy of an individual who died app 9 days after attending a pool party and swimming in a heated swimming pool. the pathologist tells you she sees Hemorrhage and necrosis. which part of the brain is most likely involved? which disease is suspected? | the frontal cortex. PAM |
| case 1b) in a public health discussion about case 1a) what preventative measure would you suggest and why? | treat swimming pools with chlorine since NAEGLERIA FOWLERI, the causative agent of PAM is susceptible to chlorine. |
| in treating an infection with NAEGLERIA FOWLERI which medication is used? | AMPHOTERIUM B, MICONAZOLE AND RIFAMPIN ( wellz., administered how?) |
