| THE most poisinous substance known, one aerosolised gram can kill 1 million people? | botulin: can be released as aerosol or contaminant in food. can include expensive long term care. |
| gram pos, rod shaped, spore forming organism that can last for up to 30 yrs | Clostridium Botulinum. |
| there are 7 types of botulism. types A-G, infection of mammals occurs in? | ABE and F: human illness
C and D: birds and mammals
G: unknown |
| types of botulism | food bourne, intestinal (infant/children and adults)
wound, inhaled. |
| the pathology of each type of botulism occurs in different time frame, which are? | ingestion: unknown
food bourne: 6- 8 hrs
wound: 4-14 days
inhalation: 24-36hrs |
| the pathology of which form of botulism occurs fastest | food bourne |
| Mode of action of botulism | 1)toxin enters blood stream
2) binds to peripheral nerve endings
3) inhibits release of Ach. thus preventing muscle contraction |
| symptoms of Botulism infection | symmetrical descending paralysis beginning with cranial nerves resuting in airway obstruction/ paralysis of respiratory muscles. |
| the infection that results in paralysis of respiratory muscles ? | botulism |
| prolonged ventilatory support and intensive care can result in secondary complication of ? | botulism infection |
| transmission of botulism occurs? | home canned goods (food bourne)
honey ( ingested)
crush injuries, injection drug use (wound) |
| concerning botulism, it is recommended that honey is not given to infants <12 months because? | honey may contai spores of Botulism which can cause ingestion botulism in infants |
| symptoms of botulism poisoning | double/ blurred vision
drooping eyelids
slurred speech
difficulty swallowing.
most patient are afebrile and alert |
| symptoms botulism infection ininfants | weak cry, poor feeding, constipation , poor muscle tone, floppy baby syndrome |
| treatment of botulism? | antitoxin administration.
supply ventilation care, body positioning and parenteral nutrition. elimination: induce vomiting, high enemas |
