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level: Level 9 - VIDEO LEC 4

Questions and Answers List

PROTEIN SYNTHESIS INHIBITORS

level questions: Level 9 - VIDEO LEC 4

QuestionAnswer
1 large ribosomal subunit 2 small ribosomal subunit1) 50s ribosomal subunit 2) 30s ribosomal subunit
BACTERIOSTATIC, for GRAM-POSITIVE AND GRAM-NEGATIVE; Attack the 50s ribosomal subunit. MOA: inhibit the ribosome from moving along the mRNA. They prevent the actual elongation of the peptide chain. so they inhibit from reading or moving along the mRNA. CAN TREAT: 1 PNEUMONIA, 2 H. PYLORI, 3 GASTROINTESTINAL TRACT INFECTIONS, 4 SEXUALLY TRANSMITTED DISEASESMacrolides
1 Antibiotics that target 50s 2 Antibiotic that targets 30s subunit1)1 Macrolides 2 Aminoglycoside 2) Tetracycline
Macrolides LIST attack the 50s ribosomal subunit.■ Erythromycin ■ Azithromycin ■ Clarithromycin- better for gram-negative coverage
1 Can cause Pneumonia 2 Cause peptic ulcers 3 caused by the campylobacter 4 STDs1) 1 Legionella 2 mycoplasma 2 H pylori 3 GIT Infections 4 chlamydia and gonorrhea
-TARGET THE 50S SUBUNIT -TREAT MAINLY GRAM-NEGATIVE, but has (+) coverage: ○ Pseudomonas- gram-negative bacteria. ○ certain typed of Aerobic gram-negative bacteria ○ Enterobacteria- gram-negative MOA: transfer RNA is carrying specifically the ANTICODON complimentary to the codons. and then they're carrying a SPECIFIC AMINO ACID that's specific to those codons. BLOCKS THE tRNA that goes to the A site CAN TREAT: ○ URINARY TRACT INFECTIONS ○ PNEUMONIA ○ MENINGITIS ○ PERITONITISAminoglycoside
1 Aminoglycosides LIST 2 Tetracyclines LIST1 ○ Gentamycin ○ Tobramycin 2 Doxycycline
BACTERIOSTATIC MOA: has the similar effect to the aminoglycosides; TARGETING 30S RIBOSOMAL SUBUNIT and PREVENTS THE TRNA from preventing from coming into the A SITE and allowing to read codons in the mRNA. Treat: ○ LYME’S DISEASE - caused by Borrelia burgdorferi protein. ○ CHLAMYDIA ○ ACNE ○ BUBONIC PLAGUE - caused by Yersinia pestis ○ ANTHRAX ○ PNEUMONIA caused by Legionella bacteria,Tetracycline