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level: Chronic Inflammation

Questions and Answers List

level questions: Chronic Inflammation

Question	Answer
Site of progenitor T-cell maturation to become CD4+ helper T cell or CD8+ cytotoxic t-cell; TCR undergoes rearrangement to form TCR complex with CD3	Thymus
Part of the TCR complex used for antigen surveillance	CD3
CD4+ T cells (4 x 2 = 8)	MHC Class II
CD8+ T cells (8 x 1 = 8)	MHC Class I
Binds to B7 protein on APC which serves as 2nd activating signal to CD4+ T-cells (7x4=28)	CD28
Activated CD4+ helper T cell which secretes IL-2 and IFN-y	TH1 subset
T-cell growth factor; CD8+ T cell activator (2nd activating signal for CD8+ T cells)	IL-2
Macrophage activator, converts macrophages to epithelioid histiocytes and giant cells	IFN-y
Activated CD4+ helper T cell which secretes IL-4, IL-5,IL-10	TH2 subset
Facilitates B-cell class switching to IgG and IgE	IL-4
Eosinophil chemotaxis and activation, maturation of B cells to plasma cells and class switching to IgA	IL-5
Anti-inflammatory cytokine, inhibits TH1 phenotype	IL-10
Perforin and Granzyme release-> apoptosis; FasL expression -> apoptosis	CD8+ Cytotoxic T cell killing
Surface immunoglobulins for naïve B cells	IgM and IgD
Located on B-cell, binds with CD40L from helper T-cell to provide 2nd activation signal	CD40 receptor
Epithelioid histiocytes	Hallmark of granulomatous inflammation
Activated macrophages with abundant pink cytoplasm	Epithelioid histiocytes
No central necrosis; Arises from foreign materials, sarcoidosis, beryllium exposure, Crohn's disease, cat scratch disease	Noncaseating granuloma
With central necrosis; Associated with Tuberculosis and fungal infection	Caseating granuloma
Stellate shape granuloma	Characteristic finding for cat scratch disease
Secreted by activated macrophages to induce CD4+ helper T-cells to differentiate into TH1 subtype	IL-12