| A manufacturer who produces the products of a company without manufacturing facilities is a/ an: | toll manufacturer |
| Primary package system as differentiated from secondary package systems: | have a direct effect on product shelf life &are in direct contact with the product |
| The only true tamper resistant packaging: | aerosol containers |
| Purified water that is free from pyrogen | water for injection |
| Viscosity enhancers are added to liquid preparations to: | improve pourability of products from container & improve palatability |
| The most inert grade of stainless steel used for high grade products | SS 316 |
| Filtration system which is recommended for handling large quantities is | pressure |
| Filling method which is advisable for highly viscous products | gravimetric filling |
| The advantages of emulsion over other dosage forms include: | increased therapeutic effects ,ability to mask unpleasant odors, increased spreading ability |
| Aggregates of powders which adhere or bond to each other to form larger particles | granules |
| Storage conditions for capsules | 21-25ºC,35-50% RH |
| Substance that “glue” powder together causing them to form granules | binder |
| An agent that acts between surfaces in relative motion to prevent friction and wear | lubricant |
| In film coating, when additives migrate to the surface, the problem is called: | sweating |
| An anteroom which separates the sterile from non sterile is a/an: | airlock |
| Area with no more than 100 particles of 0.5 micron size per cubic foot of environment: | Class 100 |
| A very simple, sensitive and fast test for pyrogens using the amoebocyte of the horse shoe crab. | LAL Test |
| Ampules are sealed by: | Pull sealing &. Tip sealinge |
| The period in which the product remain acceptable for use: | Shelf life |
| Flow property of liquid is related to: | Viscosity |
| Dispensing equipment in the name of suspension includes: | Blenders ,Colloid mill & Impellers |
| A suspension may be stabilized through the use of: | Suspending agents ,Viscosity enhancing agents, Hydrocolloid |
| Suspensions are evaluated by: | "Sedimentation, Measuring of Particle size,& Ease of redispersability |
| The ff are natural emulsifying agent, except: | Tween 80 |
| Water soluble abases are prepared from | PEG |
| Polyols may be used as: | humectant in creams |
| Preservatives are added to semisolid preparations to be prevent the ff except | container |
| Mixing equipment for acid materials | Sigma blade mixer |
| An ideal drug delivery system (DDS) is | capable of controlled delivery rates,not highly sensitive to physiological variables,c. based on physicochemical principles |
| Filtration process wherein the liquid passes through one filter pad or disk | parallel |
| A gravity operated filling set up is used for liquids which are | free flowing |
| Suspension adjunct used to prevent the product from drying at topical application | humectant |
| The aggregation of the dispersed globules into loose clusters within the emulsion | flocculation |
| CGMP means | Current Good Manufacturing Practice |
| Group which is responsible for auditing the control system for evaluating product quality | Quality assurance |
| The disintegration medium of plain uncoated tablet is | Distilled water |
| Quality control test that are performed on granules before compression into tablets are except: | angle of repose |
| The most common method of tableting active ingredients which are chemically incompatible | use double layer tableting |
| Sealing of ampule is done by | Pull sealing &. Tip sealinge |
| Bullet shaped capsules are called | pulbules |
| This is used to increase the resistance of gas | Sulfur dioxide |
| The animal of choice for in vitro rectal absorption studies | dog |
| Method that will produce tablets of best quality | wet granulation |
| Bubble test measure the efficiency of: | membrane filter |
| A processing problem encountered only in the manufacture of tablets: | double impression |
| The coalescence of oil globules in a o/w emulsion is called: | cracking |
| The ff. are true for Spans, except: | they have high HLB values |
| A variation of dry gum method of preparing emulsions using volatile oil is added to acacia in a bottle: | Bottle method |
| Antioxidants which block an oxidative chain reaction in which they are not usually consumed: | BHT |
| These are gas sterilants, except: | carbon dioxide |
| A sterilization method which destroys microorganism b y cellular protein coagulation: | autoclaving |
| The usual contaminants of ophthalmic preparations are the ff., except: | Staphylococcus aureus |
| A commonly used capsule diluent: | lactose |
| An opacifying agent for capsules: | titanium oxide |
| A common levigating agent: | mineral oil: |
| Method used for the incorporation of small amounts of potent drugs with a large amount of diluent:: | geometric dilution |
| The ff. excipients impart satisfactory compression characteristics to the tablet formulation except: | disintegrant |
| Tablet weight is determined by: | volumetric fill of the disc |
| One part of a slightly soluble material will dissolve in ________ part of solvent | 100-1000 |
| Brandy and whiskey are classified as: | spirits |
| The reduction of camphor with the aid of alcohol is called: | pulverization by intervention |
| The prominently printed element on the label: | generic name |
| Invert sugar has the tendency to darken in color due to: | levulose |
| A near saturated solution of sucrose in water: | simple syrup |
| simple syrup | 35 |
| Thixotropy is a characteristic demonstrated by: | gels |
| Galenicals are also called: | extractives |
| The injection of large of volumes of a solution into substances tissue to provide a continuous, abundant drug supply is called: | hypodermicyclics |
| Excessive use of binders in tablet affectd: | all |
| Impart cohesive qualities to the tablet granulation: | binder |
| Buccal tablets are intended to be dissolved: | swallow |
| These are necessary components of a stable emulsion, except: | electrolyte |
| Problem often encountered in suspensions: | caking |
| The different methods of determining the emulsion type are the ff., except: | Dry Gum |
| The container of choice for parenteral: | glass |
| The container of choice for ointments: | collapsible tubes |
| Which of the ff. is not classified as a lubricant? | lactose |
| Spans & Tweens are: | surfactants |
| Filtration of a solution to a high degree of clarity: | polishing |
| These are advantages of tablets, except: | prolonged dissolution |
| HEPA filters are used for filtration of: | air |
| For compacting the materials in the tablet machine: | punches |
| Tablet granulations can be dried faster using: | fluid bed dryer |
| The partial or complete separation of the top or bottom of a tablet from the main body: | capping |
| Used for mixing powder mixtures in large volume quantity: | V-blender |
| A roller mill is used to reduce the particle size of powders in: | ointment |
| This is not part of the master formula record: | price per dosage unit |
| This part of the sugar coating process is to round off tablet contours rapidly: | subcoating |
| Disintegrant | Starch |
| Filler | Lactose |
| Active Ingredient | Primaquine PO 4 |
| Binder | PVP |
| Lubricant | Stearic acid |
| Which of the ff additives in parenterals reduces the f\pain of injection in areas with nerve endings? | tonicity adjusters |
| Weight variation test is carried out iin: | 20 tabs |
| The water resistance of glass containers is tested by | amount of alkali released into water |
| Primary packaging components except | labels |
| The degree of freedom is used in calculation of | standard deviation |
| To control microorganisms in the air is to | install UV lamps in several areas |
| The work “quality” SQC refers to characteristic of a product from: | quantitative &qualitative |
| The measure of the variation of individual observations around the average is: | standard deviation |
| Advantages of plastic containers over glass, except: | permeability |
| In labeling of a product, an unlabeled portion is provided for | viewing the contents |
| The material present in both enteric and film coating | cellulose acetate phthalate |
| lyophobic substance is easily wet by | nonpolar solvents |
| Characteristics of iirigation solutions to wash wounds and body cavitites may be | sterile &pyrogen free |
| Plastic material used for ophthalmic solutions as package and applicator is | polyethylene |
| A colloid mill is used for the ff, except: | granulation |
| Use of buffers in parenterals | pH stabilizer &tonicity contributor |
| Foam in emulsion is prevented | apply compressed air &add antifoaming agent |
| the dispensing division of the warehouse requires | licensed pharmacist |
| Room temperature recognized by USP is | temp at the working area |
| Uneven distribution of colors on the surface of tablets is | mottling |
| The Board of Trustees of a company functions as the | protector of the company’s asset &prepare policies |
| The inspection and checking section of QC is responsible for | sampling of raw materials |
| The part of the transdermal drug delivery system patch where the drug is stored | reservoir |
| Practical method of determining method of hardness is | Rule of Thumb |
| Method of tablet manufacture for easily compressible or adhesive ing is | direct compression |
| Limulus amoebocyte lysate is obtained from | king crab |
| Stoke’s Monsanto tester is used to measure | hardness |
| Hemodialysis is employed to remove toxins from the | blood |
| Implantation pellets are those which contain | active ing |
| In the manufacture of semisolid emulsions, the mixing of the oil and aqueous phases is done at the temperature of: | 70-72ºC |
| Hard gelatin capsules are also referred to as: | dry-filled capsules |
| To identify pharm. Products that are registered in BFAD, the label consists of: | DR number |
| Quarantined materials delivered in the warehouse are: | subject to test and assay |
| Advantage of liquid medicines: | rapidly absorbed in the body |
| Instability of drug substances in liquid form may be caused by: | variation in pH&light of radiation |
| Disadvantage of glass material used in packaging of liquids is: | releases insoluble flakes upon storage |
| To increase viscosity of the aqueous phase of an emulsion is to: | add dissolved macromolecules |
| In suspension formulation, the suspension adjuvants may be | buffers |
| Suspending agents added to suspension formulations, except: | parabens |
| In semisolid preparations, petrolatum is a common hydrocarbon base due to its: | consistency |
| Large volume parenterals are employed for: | maintenance therapy &replacement therapy |
