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level: Lecture 9: Joint Pathology 2

Questions and Answers List

Rheumatoid Artheritis (RA)

level questions: Lecture 9: Joint Pathology 2

QuestionAnswer
An inflammitory condition characterized by polyarthritis (artheritis in 5, or more, joints; early on it can effect fewer).What is rheumatoid artheritis?
Synovial Tissue is mainly affected by this type of artheritis.What does rheumatoid artheritis (RA) specifically affect in joints?
Type A: Macrophage Derived (Of Phagocyte Origin; Responsible for absorbing bacteria) Type B: Fibroblast Derived; responsible for the creation of collagen, fibronectin, laminin and synovial matrixWhat are the two cell-type origins of Synovial Tissue?
What contributes to the viscous (thickness of a liquid) nature of synovial fluid?What is the purpose of Hyaluronan?
What glycosaminoglycan (a sugar molecule type) lubricates the surface of articular cartillage?What is the purpose of Lubricin?
The joint is swollen (likely red, due to hypervascularization), and quite possibly disfigured somewhat (due to pannus formation).What are the visual characteristics of a joint affected by RA?
_______ is an abnormal layer of fibrovascular tissue or granulation tissue (it is not limited to joints).What is "pannus formation"?
False; Rheumatoid artheritis is symmetric.True or false: rheumatoid artheritis is asymmetric.
All the joints from the wrist-down, as illustrated.What joints are effected by Rheumatoid Artheritis?
Top to bottom: Mallet Finger, Boutonnièr Deformity, Swan Neck Deformity.Label "Swan Neck Deformity," Mallet Finger," and "Boutonnièr Deformity".
Baker's Cyst; appears in the "knee pit" (as opposed to "arm pit" in annalogy)What is the name of this cyst?
Misalignment/Sublaxation of the C1 and C2 vertebrae Baker's Cyst (back of knee) Hand deformities (Mallet Finger, Boutonnièr Deformity, Swan Neck Deformity) Large joints, such as the shoulders, and knees Rarely: the lumbar and thoracic areas. Wrist Deformities.Name as many possible deformities/deformed areas you might find in a patient with RA.
Constitutional: malaise, fatigue, weightloss, depression, high fever (signs of infection). Subcutaneous nodules, spleen, Heart Disease Vascular and Sjogren`s syndrome, Anemia, renalWhat are some possible extra-articular (non-articular) feature areas of Rheumatoid Artheritis?
Rheumatoid Artheritis (RA)What is the general malady being shown in this image?
a and d are the ONLY correct answers for a DOMP.What of the following treatments are within a DOMP's ethical right to recommend for an RA patient: a) NSAIDs, b) Glucocorticoids, c) DMARDs (disease-modifying antirheumatic drugs), d) Physical Therapy and Assistive Devices. e) Surgery.