Mild to moderate depression, anxiety, viral infection, insomnia, premenstrual syndrome, topical myalgia, inflammation there are numerous case reports and clinical trials evaluating the efficacy and safety of st. johns wort. most trials contain design flaws, but overall results suggest that St.johns wort is sometimes beneficial for mild to moderate depression. adverse reactions, which are uncommon, include photosensitivity, constipation, vertigo, dry mouth, restlessness, and sleep disturbance. patients should avoid concurrent use MAOIs, alcoholic beverages, opioids, prescription antidepressants, sympathomimetics, and foods such as chocolate, aged cheeses, and beer. do not give to children