15 years Randomized data on men in 50-60 For every 1000 men screened, 1-2 deaths prevented and 3 avoid metastatic prostate cancer. 20-50 men will be overdiagnosed: finding small cancer which would not impact life if not found. Treating these provides not benefit only harm ( 60% incontinent/ ED, and > 20% with unnecessary bx) Controversial as 15% of men in US will be dx with but only few will die from it 2.8%. Screening reduces risk from dying prostate cancer for a small number of cases.