Virulence factors of S. pyogens

1)Hemolysins/streptolysis O(antigenic) and S: lyses RBC and WBC 2) streptokinase: activates plasminogen to lyse fibrin clots 3) DNAases: hydrolyses DNA 4)NADases: hydrolyses NAD 5) Hyaluronidase: breaks down proteoglycans/ host connective tissue 6)pyrogenic exotoxins: consist of erthrogenic toxins A,B and C. stimulate Tcells to binding to class 2 MHC directly or non specifically. 7) proteases: soft tissue nercrosis or toxic shock syndrome