Gamma-Amino-Butyric Acid (GABA) - ADDICTION

Inhibitory neurotransmitter blocks impulses between nerve cells and the brain (CNS) - Inhibits dopamine release Opioid (Mu) receptors on GABA neuron nerves - opioid may bind and inhibit GABA = increased dopamine production = euphoria Desensitisation in heroin addicts - need a higher dose for response