BB lecture: • Polyspecific AHG (Polyvalent or broad-spectrum Coombs’ serum)

Question

•	Polyspecific AHG (Polyvalent or broad-spectrum Coombs’ serum)

Ellyn Mae Armada · Accepted Answer

	Contains antibodies to both IgG and complement (can detect IgM)
	Antibody to C3 component (CD3) are more desirable in the reagent, as these are more abundant on the RBC surface during complement activation and lead to fewer false-positive reactions.

BB lecture

• Polyspecific AHG (Polyvalent or broad-spectrum Coombs’ serum)

 Contains antibodies to both IgG and complement (can detect IgM)  Antibody to C3 component (CD3) are more desirable in the reagent, as these are more abundant on the RBC surface during complement activation and lead to fewer false-positive reactions.

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