Infective Endocarditis: Staphylococcal Treatment

- Native 4-6 weeks: Oxacillin / Cloxacillin 12g/day IV in (4-6 doses >6 weeks) -if methicillin susceptible - Prosthetic > 6 weeks: Oxacillin/ cloxacillin 12g/day IV (4-6 doses) + Rifampin 900-1200mg IV or orally (2-3 doses) + Gentamycin 3mg/kg/day IV/IM (1or 2 doses for 2 weeks) - MRSA: Vancomycin + Rifampin + Gentamycin for >6weeks (alternative: Daptomycin)