MCB L9-10: Initiation of protein synthesis in eukaryotes

Question

Initiation of protein synthesis in eukaryotes

Alex Rapai · Accepted Answer

AUG is almost always used as the initiation codon. A special initiator tRNA, tRNAimet is used as the initiator. (Does not become formylated). tRNAmmet is used to insert internal methionines. 
The “first” AUG is usually use for initiation (~90%). Context dependent.

MCB L9-10

Initiation of protein synthesis in eukaryotes

AUG is almost always used as the initiation codon. A special initiator tRNA, tRNAimet is used as the initiator. (Does not become formylated). tRNAmmet is used to insert internal methionines. The “first” AUG is usually use for initiation (~90%). Context dependent.

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