Translational control mechanisms

Regulation of the activities of initiation and/or elongation factors by phosphorylation (pro- and eukaryotes). Blocking / opening of ribosome binding sites by reversible changes in secondary structure (prokaryotes). Autogenous regulation. Protein product of a gene binds to ribosome binding site in mRNA, preventing initiation (prokaryotes). Reversible binding of a repressor protein to a response element in 5’ UTR (eukaryotes). Differential stability of mRNA.