MCB L11-12: Ire1 also has a general RNase activity (RIDD) and can also stimulate signalling via c-Jun N-terminal kinase (JNK).

Question

Ire1 also has a general RNase activity (RIDD) and can also stimulate signalling via c-Jun N-terminal kinase (JNK).

Alex Rapai · Accepted Answer

Transcription factor- to nucleus: Increase ERAD, folding and trafficking. Regulated IRE1 dependent 
decay of mRNA (RIDD): Regulated IRE1 dependent decay of mRNA (RIDD). RIDD degrades mRNA in complex with ER-associated ribosomes.

MCB L11-12

Ire1 also has a general RNase activity (RIDD) and can also stimulate signalling via c-Jun N-terminal kinase (JNK).

Transcription factor- to nucleus: Increase ERAD, folding and trafficking. Regulated IRE1 dependent decay of mRNA (RIDD): Regulated IRE1 dependent decay of mRNA (RIDD). RIDD degrades mRNA in complex with ER-associated ribosomes.

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