Dynein movement

Dynein moves exclusively towards the minus end of microtubules. However, unlike kinesin, it cannot mediate cargo transport by itself. Rather it requires an 11 subunit complex called the Dynactin complex. This contains Dynactin which also has a microtubule binding domain of its own and other proteins including Arp1 (an actin related protein) which forms a mini actin-like filament that is responsible for cargo binding.