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MCB L17-18

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Question:

Actin binding toxins and the residues required for their binding on the actin monomer

Author: Alex Rapai



Answer:

Cytochalasin D: Binds monomers and barbed ends, inhibits polymerization. Tolytoxin: Binds monomers and barbed ends, inhibits polymerization 1Kx more effective. Latrunculin A: Binds monomers and inhibits polymerization. Phalloidin: Binds and stabilizes F-actin, can be labelled with a fluorescent dye, making it very useful for staining actin filaments in cells.


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