WUS regulates transcription of the CLV3 gene.

WUSHEL (WOX) and CLAVATA function as part of a transcriptional feedback loop. Organising centre cells express WUS. They signal to neighbouring stem cells to express CLV. CLV-expressing cells signal to the organising centre to reduce WUS expression – resulting reduced CLV expression in stem cells. This acts to limit the pool of both organising centre and stem cells. Cell that express CLV are unable to differentiate and retain stem cell identity. As cells divide, they are gradually pushed away from WUS-expressing cells and receive less signal from WUS. As a result, they express less CLV and become able to differentiate