Clofazimine is a membrane-disrupting agent

Killing mechanisms of membrane-damaging agents: Toroidal pore formation, aggregation of the antimicrobial bends the lipid bilayer, forming a pore. Barrel-stave pore formation: the hydrophobic portion of the antimicrobial aligns with membrane lipids, with the hydrophilic portion facing inward to form a pore. Carpet-like pore formation: coating of the bilayer is proposed to result in micelle formation and membrane dissolution.