Symptoms and treatment

Early symptoms of toxoplasmic encephalitis include headache, fever, lethargy, and altered mental status with progression to neurological deficits and convulsions. The disease is almost always due to a reactivation of a latent infection and tends to remain confined to the CNS. The recommended treatment is the synergistic combination of pyrimethamine plus sulfadiazine. Interfere with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase. Spiramycin for prophylactic use during pregnancy.