Precise method of locating and destroying sharply circumscribed lesions on specific, tiny areas of pathological tissue in deep-seated structures of the central nervous system; also called stereotaxy or stereotactic surgery. This is used in the treatment of seizure disorders, aneurysms, brain tumors, and many other neuropathological conditions and is performed without a surgical incision. The site to be worked on is localized with three-dimensional coordinates, and methods of destroying lesions include heat, cold, and radiation.