Bacterial/Cellular Features Established Lesion

Plaque biofilm extends subgingivally into the junctional epithelium Cytokines recruit more cellular defenders due to increased subgingival bacteria These cellular defenders (PNMs, macrophages, lymphocytes- B&T cells, plasma cells-produce antibodies) migrate to the site of infection and destroy connective tissue in the process Established gingivitis is reversable when professionally treated, if not advanced lesion/periodontitis occurs