Endocrinology: What is the role of GH in glycemia?

Question

What is the role of GH in glycemia?

H K · Accepted Answer

GH stimulates liver to produce IGF
IGF-1 increases insulin sensitivity, GH stimulates gluconeogenesis, lipolysis causing hyperglycemia, but also causes increased insulin resistance, resulting in hyperinsulinemia.
But in acromegaly pt, IGF1 isn't able to overcome insulin-resistant state by GH.

Endocrinology

What is the role of GH in glycemia?

GH stimulates liver to produce IGF IGF-1 increases insulin sensitivity, GH stimulates gluconeogenesis, lipolysis causing hyperglycemia, but also causes increased insulin resistance, resulting in hyperinsulinemia. But in acromegaly pt, IGF1 isn't able to overcome insulin-resistant state by GH.

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