F. TOXICITY RESULTING FROM DYSREPAIR 3) Carcinogenesis ; c) Failure to terminate Proliferation: Promotion of Mutation, Proto- Oncogene Expression, and Clonal Growth 1 ENHANCED MITOTIC ACTIVITY PROMOTES CARCINOGENESIS for a number of reasons:

. 1. Enhanced mitotic activity increases the probability of mutations 2 Overproduced protooncogene proteins cooperate with oncogene proteins to facilitate the neoplastic transformation of cells 3 Cell to cell communication are temporarily disrupted during proliferation; contributes to the invasiveness of tumor cells