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ARNOLD STERN pcol

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Question:

It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was

Author: Jearrie Jean Sumagang

It was determined that 95% of an oral 80-mg dose of verapamil was
absorbed in a 70-kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability
of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min,
the hepatic clearance of verapamil in this situation was



Answer:

1425 mL/min


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