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pharmacology chemotherapy

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Question:

Ethambutol mechanism

Author: Suzuki



Answer:

It inhibits arabinosyltransferases (encoded by the embCAB operon) involved in the synthesis of arabinogalactan, a component of mycobacterial cell walls. Resistance occurs rapidly via mutations in the emb gene if the drug is used alone. it is bacteriostatic Resistance is not a serious problem if the drug is employed with other antitubercular agents.


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Suzuki
Suzuki