Micafungin and anidulafungin

Micafungin and anidulafungin are the newer members of the echinocandins class of antifungal drugs. Micafungin and anidulafungin have similar efficacy against Candida species, but the efficacy for treatment of other fungal infections has not been established. The dose of micafungin and anidulafungin does not need to be adjusted in renal impairment or mild-to-moderate hepatic dysfunction. The half-life of micafungin is slightly longer, and that of anidulafungin is 24–48 h. Micafungin does not require a loading dose. Micofungin is used for mucocutaneous candidiasis and for prophylaxis of Candida infections in bone marrow transplant patients. Micafungin also causes histamine release and elevates blood levels of the immunosuppressant drugs cyclosporine and sirolimus. Micofungin is used for mucocutaneous candidiasis and for prophylaxis of Candida infections in bone marrow transplant patients.