2. Distribution:

Concentrations in CSF are inadequate, even when the meninges are infl amed. Except for neomycin, the aminoglycosides may be administered intrathecally or IV. High concentrations accumulate in the renal cortex and in the endolymph and perilymph of the inner ear, which may account for their nephrotoxic and ototoxic potential. All aminoglycosides cross the placental barrier and may accumulate in fetal plasma and amniotic fluid.