Pharmacokinetics ssri

All of the SSRIs are well absorbed after oral administration. Peak levels are seen in approximately 2 to 8 hours on average. Food has little effect on absorption (except with sertraline, for which food increases its absorption). Only sertraline undergoes significant first-pass metabolism. The majority of SSRIs have plasma half-lives that range between 16 and 36 hours. Metabolism by cytochrome P450 (CYP450)-dependent enzymes and glucuronide or sulfate conjugation occur extensively. [Note: These metabolites do not generally contribute to the pharmacologic activity.]