Extrapyrimdal effects of different drugs

Those drugs that exhibit strong anticholinergic activity, such as thioridazine, show fewer extrapyramidal disturbances, because the cholinergic activity is strongly dampened. This contrasts with haloperidol and fluphenazine, which have low anticholinergic activity and produce extrapyramidal effects more frequently because of the preferential blocking of dopaminergic transmission without the blocking of cholinergic activity.