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CNS Pharmacology

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Question:

Phenytoin pharmacokinetics

Author: Suzuki



Answer:

Phenytoin exhibits saturable enzyme metabolism at a low serum concentration. Therefore, knowledge of zero-order pharmacokinetics and population parameters is important for dosing adjustment. Small increases in a daily dose can produce large increases in the plasma concentration, resulting in druginduced toxicity.


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Author

Suzuki
Suzuki