Is an analgesic and antipyretic, but it is not an anti-inflammatory substance. blocks pain impulses peripherally that occur in response to inhibition of prostaglandin synthesis, so it does not have anti-inflammatory properties. Its antipyretic action results from inhibition of prostaglandin synthesis in the CNS at the hypothalamic heat-regulating center. While this has milder effects on the upper digestive tract than other over-the counter pain relievers, it can have serious side effects in cases of overdose or long-term therapy such as renal failure and hepatic toxicity. This agent should be used with caution in patients who have renal or hepatic disease and should not be taken with alcohol. does not decrease platelet aggregation and, therefore, is less likely to affect clotting capacity, which makes it a safer choice for hemophiliacs, patients taking “blood thinners,” and for children. It is often used as a first-line medication in conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.