MANUFACTURE FINALS:  The PREFERRED METHOD IN GRANULATION
 TABLETS are COMPRESSED DIRECTLY from powder blends of active and suitable ingredients

 USES DIRECTLY COMPRESSIBLE VEHICLE such as
Anhydrous lactose, Spray-dried lactose, Crystalline
sorbitol, Dicalcium phosphate dihydrate, Granular
mannitol, and Avicel

 The ingredients incorporated here SHOULD POSSESS
INHERENT COHESIVENESS & GOOD FLOW PROPERTIES

(STATE THE LIMITATIONS)

Question

 The PREFERRED METHOD IN GRANULATION
 TABLETS are COMPRESSED DIRECTLY from powder blends of active and suitable ingredients

 USES DIRECTLY COMPRESSIBLE VEHICLE such as 
Anhydrous lactose, Spray-dried lactose, Crystalline 
sorbitol, Dicalcium phosphate dihydrate, Granular 
mannitol, and Avicel

 The ingredients incorporated here SHOULD POSSESS 
INHERENT COHESIVENESS & GOOD FLOW PROPERTIES

(STATE THE LIMITATIONS)

LEIGHTON DWIGHT OBILLOS · Accepted Answer

Direct Compression

LIMITATIONS:
- Stratification-variation in content with differences 
in size and density
- Drug limited to 30% of tablet weight unless 
directly compressible
- Interaction between amine drugs and spray-dried 
lactose
- Development of static charges which prevents 
uniform distribution

MANUFACTURE FINALS

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